Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. There is some evidence that memantine can be useful in obsessive-compulsive disorder (OCD). Klonopin--is great for my OCD type stuff but for some reason other benzos don't work the same. Worked well for about a month and now I don't feel it as much...thinking off cycling off of it for a week or two and resetting. Blunts creative thinking a bit like methylphenidate, amphetamines do, but is not nearly as bad for you. I use it until I develope a tolerance to it to where I no longer flush even at 500 mg doses and that is I then take a 3-4 days off from it. I’m also suffering from pure O OCD and just started Memantine today. However, ketamine’s other … This article was initially published in the Summer 2013 edition of the OCD Newsletter. Another drug, the N-methyl-d-aspartate antagonist memantine, has recently been tested in the treatment of OCD. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Do you cycle it at all? Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Magnesium...I'm a huge fan. It is ... A study examining self-reported misuse of memantine on the social network reddit shown that the drug was used as a recreational drug and as a nootropic, but also that it was misused in various illnesses as self-medication without strong scientific basis. Additionally, do you recommend your patients undergo CBT/ERP? Discussion of nootropics and cognitive enhancers. I am prone to addictions, ruminations, fixations. I have tried memantine for my ASD with OCD/repetitive behavior tendencies, it worked great for me do a search on my username. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. It’s pretty surprising when I take a look through the community though I’ve never tried it myself. Very few side effects, minimal tolerance and excellent potency for obsessive anxiety. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. I am a chronic suffer of Severe OCD, and have read numerous of studies of Memantine being effective for treatment resistant OCD. OCD patients also have higher plasma levels of dehydroepiandrosterone-sulfate ... Memantine (5-20mg) . Obsessive-compulsive disorder (OCD) is commonly treated with both medication and cognitive behavioral therapy.Medications that target serotonin pathways in the brain, like antidepressants, are particularly effective in treating people with OCD—and if this doesn't work, adding on an antipsychotic medication may be useful. namenda. Do you find the positive effects have lasted? It was bad enough I felt it no longer wise to drive a car. Hello. NAC (500mg-2g daily) . Chantix is usually only taken for a maximum of 6 months and takes a few weeks to kick in...but, I wonder if a psych has ever considered using it longer term or what the risks might be? Researchers examined whether adjunctive gabapentin or memantine and standard treatment with a selective serotonin-reuptake inhibitor (SSRI) might lead to further improvements in patients with OCD. 6) May Decrease Symptoms of Obsessive-Compulsive Disorder (OCD) According to some studies, memantine has shown some potential when used in addition to first-line treatments for OCD . Take one dose every day, at the same time of day each day. Most of the times are an approximation. by Christopher Pittenger, MD, PhD, & Wayne Goodman, MD. Page 1 of 3 - Memantine Has Obliterated My Depression and Social Anxiety - posted in Mental Health: Hey all, just wanted to briefly share my experience here. It is less preferred than acetylcholinesterase inhibitors such as donepezil. Source Naturals has a good one on Amazon available in a 2oz or 4oz bottle. Compulsivity is a cross-disorder trait underlying phenotypically distinct psychiatric disorders that emerge in childhood or adolescence. I'm only a few days in but will let you know regarding things like intrusive thoughts, physical compulsions and anxiety. I'm curious if smoking marijuana daily had an effect on the brain fog and positive effects of memantine. Hold liquid in mouth and do not swallow for at least 2 minutes. The only problem is that pretty much all of the pure-extracts are fake or low quality. It’s pretty surprising when I take a look through the community though I’ve never tried it myself. I just bought 10 grams primarily for a reduction in OCD symptoms. It is taken by mouth. Plus hangovers the next morning that don't exist with the liquid dose I mentioned. 23 An open‐label trial by Rodriguez et al. I read some of your previous posts on it I suffer with over self consciousness too, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425334/. Thank you. It is strange for speed (Vyvanse) to work against OCD. It's side effect profile is nearly non existent. You will be given a small dose when you first start treatment. Also seems to potentiate adderall and other meds. I'm writing a quick post to try and convince people to try what I did. N-Acetyl Cysteine completely caught me off guard as I bought it for something completely unrelated. In a randomized double-blind placebo-controlled study of memantine combined with fluoxetine published by Ghaleiha et al. The off-label use of memantine is so surprising because the benefits seem to range from memory to concentration, treatment of ADHD, OCD, manic episodes, and even libido. Self‐reported users experiences posted on reddit.com were recorded and sorted using representative keywords. It’s basically a mental condition where an individual experiences bothersome, intrusive, and worrisome thoughts that elicit a feeling of discomfort and/or fear that often leads to obsessive-compulsive behaviors. You basically either mix it into an oil (preferably coconut) and take it orally or vaporize it on it's own (never try to vaporize oil, vape fluid is propylene glycol). Oral absorption is far far lower than vape so vape is a lot more economical in the long run. i would love to try CBD but unfortunately can't because I live in a sober house. The present study investigates the effect of fluoxetine and memantine alone and in combination in a mouse model of compulsive behavior. Too many people are taking these crazy 10mg doses that burn them in the long run and paradoxically don't work as well for sleep as the 1 mg liquid. I try to write it in a way so that it doesn't seem like I'm trying to advertise a product or something lol. Request PDF | An open-label trial of memantine in treatment-resistant obsessive-compulsive disorder | Background:Obsessive-compulsive disorder (OCD) is often refractory to treatment. Press J to jump to the feed. Hi. I'm now on Venvanse and Memantine, and 50-70% covered with this combo. Most particularly compulsive behaviors. I have anxiety and depression as well, but the OCD is the worst. Memantine and ocd. The analysis included double-blind, randomized, placebo-controlled trials of memantine in MDD and BD. I disagree unless youre taking low doses. This reddit thread has some great resources to find a trust worthy vendor for the isolate (crystalline powder). It speeds me up in a good way. An open-label st… Context At the time of dosing: -I have depression, anxiety, OCD, and ADHD.-My mental health had been improving, but it back-slid over the winter break. Request PDF | On Mar 12, 2019, Ajay Bakhla and others published An open‑label trial of memantine in TT resistant OCD | Find, read and cite all the research you need on ResearchGate Four to five symptom clusters or OCD types are common, and each has its associated obsessions and compulsions [6, 7, 8]:Checking: Forbidden or instrusive thoughts (aggressive, sexual, religious, or somatic obsessions) and checking compulsions; Instrusive Thoughts: Obsessions with no clear compulsion (may involve … PURPOSE: Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist currently used for moderate-to-severe Alzheimer's disease. I seriously doubt memantine's NMDA properties were of any benefit for me, probably because I don't have anxiety or other signs of glutaminergic over-activity to begin with. Interesting. When the flush wears off, my mind feels just like I just got home from the gym and just sat down in my favorite chair....with that calm, relaxed feeling. I would say it's helped and definitely worth a try. New comments cannot be posted and votes cannot be cast. Hey everyone, I have tried many different ocd drug therapies, but have yet to try a glutamate modulating therapy such as Memantine (Namenda), Riluzole (Rilutek), N-acetyl cysteine, or amantadine. It's hard to explain. They show up for THC on a drug-test, right? Towards New Medications for Refractory OCD. Its core structure is adamantane, a diamondoid of four interlocked cyclohexane rings in a stable 3-dimensional lattice conformation. I know this is counterintuitive to do something uncomfortable to get relief...but when you know its coming and tell yourself that the flushing and itching will stop in 30-40 minutes and IS COMPLETELY normal, it really helps. I've read reports on reddit and some journals that memantine can help OCD. Page 1 of 3 - Memantine Has Obliterated My Depression and Social Anxiety - posted in Mental Health: Hey all, just wanted to briefly share my experience here. Memantine is substituted with a methyl carbon at both R3 and R5; it contains an amine substitution at R1. Memantine, or 3,5-dimethyladamantan-1-amine, is a man-made molecule classified as a substituted adamantane derivative. Some trials even reported a 100% response! Above that dose range and it gets too weird and u can come off strange and lose control a bit & it lasts a day or more. Memantine will definitely slow down racing, uncontrolled thoughts, though you may or may not like the side-effects. It can manifest in a wide variety of ways, for example : This reddit thread has some great resources to find a trust worthy vendor for the isolate (crystalline powder). 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Treating Bipolar Disorder This is why it's seen as so overrated by some, because there are so many vendors selling it in ridiculously low concentrations or lying and there's still THC in the product (if from a dispensary). You want Nictonic Acid or Niacin with no mention of "flush free" or "sustained release"...also Niacinamide is not what you want either. Pretty safe supplement. A second drug that is already available and affects how neurons respond to glutamate is memantine (Namenda®). 90% of my anxiety is linked to this. Should have it tomorrow or the next day and might have some input then. Quite the contrary. The RCTs analyzed a total of 82 patients and found a significant improvement in short-term outcomes and higher rates of remission achieved with memantine than placebo, without significantly augmented side effects. How are you feeling currently? Porn needs to be a no-go when taking that stuff. It can work the opposite too though, as I once got stuck into a 12 hour long whack off session. Cool that we are on similar combo. After reading about memantine, it seems promising. Of all the neurotransmitters, glutamate is considered the most critical for healthy brain function. But have OCD. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Common side effects … The association of OCD-schizotypal comorbidity with the beneficial effect of memantine is noteworthy in view of a pertinence of glutamatergic dysfunction in both OCD and schizophrenia spectrum disorders . Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA). If one does not mind waiting a few hours for the effects to be felt, and due to the pain involved with intramuscular injection, I believe … 11 In another case–control study, memantine was found to be effective as a glutamatergic‐augmenting agent in severe OCD. The prim … A Meta-Analysis of Memantine for Depression J Alzheimers Dis. Additionally, it’s a non-essential amino acid which means your body can synthesize it when necessary.. Glutamate is the most abundant neurotransmitter in the brain and central nervous system. It is best to take in the evening when you don't have plans to go anywhere as you will look pretty fucked up going through the flush stage. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. As far as drugs go it's pretty safe. Current psychotherapy and medication treatments for OCD can be of help to many who suffer from the disorder. There's a section on Memantine in that article as well as other treatments which were evaluated one of which I'd not heard of before which is Riluzole. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Thanks so much. Obsessive-compulsive disorder (OCD) is a mental illness that affects almost 3% of Americans. User Reviews for Memantine. Several case reports and two recent open-label case series suggest that the addition of memantine to standard medication therapy can benefit both children and adults with OCD. Consistently, glutamate-modulating agents, such as riluzole and memantine have been used in OCD treatment. Niacin, 100 to 200 mg. You want the kind that makes you flush and itch. Health food stores and Amazon are the place for this. Adding memantine to fluvoxamine in treatment of OCD also resulted in more complete response in that study. I agree with you about that some may like and others may not like the side effects, it was a mixed 50/50 like/dislike for me to be honest. Memantine the Unknown Drug Tolerance Prevention Chemical Memantine has had been a well kept secret for drug tolerance prevention. Can't really recommend Klonopin for anybody on a daily basis though. There are very few if any well designed studies on antipsychotic monotherapy for OCD. I'm taking her off of it immediately.”

I don't abuse my friends and family, my anxiety is significantly lessened, and I can act normally in social situations. Press question mark to learn the rest of the keyboard shortcuts. This article was initially published in the Summer 2013 edition of the OCD Newsletter. I've read reports on reddit and some journals that memantine can help OCD. I'd love to try it out! The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Walmart, Walgreens and grocery stores do not carry good old regular Niacin I think because they are scared to death people will take it without knowing about the harmless flush and thus send themselves to the hospital thinking they are having a reaction. Also it is indeed hard to describe how it feels like unless youve been on it yourself yes :). no side effects you say??? ey guys, long time viewer, first time poster. Some places refer to Niacinimide as Niacin and it is not the same. think of a healing plant or healing open wound. Also inositol can help with OCD and repetitive behavior but I have found the effect to not last all day and can give stomach discomfort as side effect. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. CBD's primary mechanism of action is upregulating 5HT-1A receptors (subset that among many things increases social behavior and partially mediates the relief/pleasure from social interaction (along with a bunch of other receptors obviously), increasing natural cannabinoids by slowing the enzyme that metabolizes them, by positively modulating opioid receptors (very slightly), and finally may directly modulate calcium signalling (responsible for excitation of neurons), reducing excessive flow of calcium into neurons. Press question mark to learn the rest of the keyboard shortcuts. Chantix stopped that too. Preface I forgot to write this all in one place again so this is just pieced together from various notes, text messages, and browsing history I could scrape together. Common Questions and Answers about Memantine and ocd. I've tried SSRIs, almost all of them, and hated them. Towards New Medications for Refractory OCD. Moreover, augmentation therapy with amantadine and memantine, another glutamate modulator, was used in open‐label studies in OCD patients who had failed to respond properly to SRI with promising results. The obsessions and compulsions can be unique to each individual. It does not discriminate; it is said that several celebrities have come out to talk about their struggles with OCD from soccer legend David Beckham to superstar Justin Timberlake. As while it appears to be a very effective tool for numerous of psychiatric illness, the frequent mention of the development of tolerance in this Sub-Reddit, is disappointing . Memantine's suggested neuroprotective effect 2,8 may also increase brain levels of the neuronal marker, N-acetyl aspartate (NAA).Because NAA is found primarily on neuronal axons in the brain, 9 perhaps the neuroprotective effect of memantine can be measured by quantifying the change in NAA concentrations in brain tissue via magnetic resonance spectroscopy. ... Reddit; Most popular articles. Also known as: Namenda, Namenda XR Memantine has an average rating of 5.3 out of 10 from a total of 55 ratings on Drugs.com. 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